Single-trial Neuromagnetic Analysis of Auditory Steady State Responses and Its Application for the Studies of Chronic Tinnitus
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چکیده
1 I N T R O D U C T I O N 2 1.1 Definition 2 1.2 Epidemiology 2 1.3 The auditory system 4 1.4 Etiology 7 1.4.1 Peripheral sources of tinnitus 7 1.4.2 Central sources of tinnitus 9 1.5 The auditory Steady State Response 18 1.5.1 The nature of the auditory Steady State 18 Response 1.5.2 Application of the auditory Steady State 20 Response for research 1.6 Hypotheses 21 2 . M A T E R I A L S A N D M E T H O D S 23 2.1 Subjects 23 2.2 Experimental design 24 2.3 Stimulation 25 2.3.1 Auditory stimuli 25 2.3.2 Visual Stimuli 26 2.4 Recording 26 2.4.1 MEG Recording 26 2.4.2 Audiometric Measures and TEN-test 27 2.4.3 Tinnitus-Spectrum 27 2.4.4 Determination of the lesion edge frequency 28 2.5 Data preprocessing 28 2.6 Data analysis and Statistical Analysis 29 2.6.1 Steady State Amplitude 29 2.6.2 Dipole Locations 31 2.6.3 Phase Coherence 33
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Short-term effects of single repetitive TMS sessions on auditory evoked activity in patients with chronic tinnitus.
Subjective tinnitus is the perception of a sound without any external source. Repetitive transcranial magnetic stimulation (rTMS) has been examined as a treatment tool for chronic tinnitus for several years trying to target hyperactivity/abnormal synchronization within the auditory cortex putatively underlying the auditory phantom percept. However, its exact impact on auditory cortical activity...
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